Neonatal treatment with naloxone increases the population of Sertoli cells and sperm production in adult rats.
نویسندگان
چکیده
Endogenous opioid peptides play an important role in the ontogenesis of the functional and morphological parameters of the seminiferous epithelium. The aim of this study was to evaluate the effects of neonatal manipulations with naloxone, an opioid antagonist, on the population of Sertoli cells and on sperm production in adult rats. Rats were assigned to receive 8 mug per gram of body weight twice a day with interval of 8 h of naloxone and they were compared to a control group receiving saline. Naloxone groups presented the following findings when compared to the control group: increased body weight from the 2nd to the 27th day; a smaller seminiferous epithelium height, smaller seminiferous tubule diameter, increased number of Sertoli cells and daily sperm production per testis, increased daily sperm production per gram per testis and increased total length of the seminiferous tubule of the treated groups. According to our study, the neonatal treatment with naloxone during the critical period of testis development was able to change the proliferative dynamics of Sertoli cells by an intra and/or extra testicular blockage of opioid receptors, confirming the direct relation between the number of Sertoli cells and the number of spermatozoids.
منابع مشابه
P-3: Effects of Increased Mast Cells Number-Induced by Sulpiride Atipycal Antipsychotic Drug on Sertoli Cells and Sperm Production in Adult Male Mice
Background: Male infertility is a widespread problem and increased number of mast cells-induced by some drugs like sulpiride atipycal antipsychotic drug, ara described in the testis of males, exhibiting impaired sper-matogenesis and fertility disorders. In this study number of mast cells and sertoli cells, thickness of seminiferous tubule’s lamina propria and sperm concentration and viability i...
متن کاملP-49: Comparative Appraisal of Acarbose, Pioglitazone and Repaglinide on Histopathology of Testis in Streptozotocin Induced Diabetic Rats
Background: Experimentally induced diabetes in male rats is associated with alteration in functions of reproductive system. Acarbose, Pioglitazone and Repaglinide via decrease in blood glucose level can prevent the damage of testes. Materials and Methods: A total of 96 adult male albino rats whit a body weighing between 230- 250 g were injected by a single intraperitoneal injection of streptozo...
متن کاملP-8: The Protective Effect of Ascorbic Acid on The Germ Cells Population and Daily Sperm Production in Mice Treated with Sodium Arsenite
Background Oxidative stress has been suggested to be a major cause of reproductive failure. Arsenic as an environmental toxicant can exert malformation in the reproductive system by inducing oxidative stress. Ascorbic acid, a potent antioxidant, is able to restrict oxidative stress. The aim of this study was to investigate the adverse effect of sodium arsenite on the germ cells population and d...
متن کاملP-43: A Comparative Study of The Protective Effects of Metformin and Juglans Regia Leaves on the Alterations of Sperm Population and Motility in Adult Diabetic Rats
Background: Increase of blood glucose leads to structural and functional changes in various target tissues and organs. Gonadal dysfunction and decrease in testosterone production are the consequence of diabetes and these conditions lead to insufficient production of spermatozoids. Besides the use of chemical agents, herbal medications for treatment and reduction of diabetic side effects have be...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Reproduction, nutrition, development
دوره 46 2 شماره
صفحات -
تاریخ انتشار 2006